Tuesday, January 31, 2012

New probiotic bacteria shows promise for use in shellfish aquaculture

ScienceDaily (Jan. 30, 2012) ? The use of probiotic bacteria, isolated from naturally-occurring bacterial communities, is gaining in popularity in the aquaculture industry as the preferred, environmentally-friendly management alternative to the use of antibiotics and other antimicrobials for disease prevention. Known to the public for their use in yogurt and other foods to improve human digestion and health, probiotic bacteria isolated from other sources can also be used to improve survival, nutrition and disease prevention in larvae grown in shellfish hatcheries.

Researchers at NOAA's Milford Laboratory in Milford, Conn. have shown that naturally-occurring bacteria isolated from the digestive glands of adult eastern oysters (Crassostrea virginica) and northern bay scallops (Argopecten irradians irradians) may be used as potential probiotic candidates in oyster larviculture.

Two related research studies published in the Journal of Shellfish Research identify a new probiotic bacterium, designated OY15, which has been shown to significantly improve larval survival in pilot-scale trials during the first two weeks of life, the most critical stage for the organism when mortality rates are among the highest.

"We are cautiously optimistic that this probiotic candidate, OY15, will offer a number of significant benefits to the shellfish industry," said Gary Wikfors, co-author of both studies and head of the Milford Laboratory's Biotechnology Branch. "Commercial and public shellfish hatcheries can have low survival rates for shellfish seed during the first two weeks, so improving those survival rates and the health of the organisms beyond that point is a pretty significant step forward."

Hatcheries produce shellfish seed to supplement natural seed, which is often limited by loss of habitat, contamination from pollution, climate change and other factors. Bacterial diseases caused mainly by pathogenic bacteria such as Vibrio are a major cause of mortality in hatchery shellfish, particularly at the very early larval stage. The result: significant financial losses to commercial growers and to production of farmed shellfish, which accounts for 25 percent of the total world aquaculture product.

Antimicrobial drugs approved for use in aquaculture in some countries, but not the US, have traditionally been used to treat bacterial diseases, but overuse of antibiotics can result in the development of resistant strains of bacterial pathogens. The use of probiotic bacteria has become increasingly popular for improved nutrition, healthy digestion and disease prevention and is used in human foods like yogurt and in pet foods.

As demand for environmentally-friendly aquaculture grows, the use of probiotics for disease prevention and improved nutrition in shellfish aquaculture is also growing. While a number of research studies have shown promise, development of probiotics that can be used in aquaculture is a multistep process requiring fundamental research and full-scale trials.

"The objective of the first part of this study was to isolate and evaluate new probiotic bacteria which, when incorporated into foods used in shellfish hatcheries, might significantly improve larval survival," said co-author Diane Kapareiko, a microbiologist at the Milford Laboratory. The second part of the study was to test the new probiotic candidate on the survival of oyster larvae in pilot-scale trials during their first two weeks of life.

"We conducted a very cautious, step by step study, to identify the best candidates under a variety of scenarios," Wikfors said. "Our bench-scale challenge studies indicated that oyster larvae exposed to probiotic candidate OY15 had the highest survival rate, and that the survival of pathogen-challenged larvae was further improved by the presence of OY 15 compared to the pathogen alone. It is somewhat analogous to a human building up immunity to a certain organism by being exposed to it, but without the involvement of antibodies."

The Milford scientists isolated 26 candidate probiotic bacteria from oysters and scallops of which 16 had an inhibitory effect against a known shellfish-larval pathogen (B183) of the Vibrio species of bacteria. Further screening for safe use in culturing the oyster larvae and their microalgal feed indicated which probiotic candidates would inhibit growth of the pathogen most effectively and therefore could confer a protective effect upon oyster larval survival.

Lab studies indicated that survival of two-day old oyster larvae during two-week pilot scale trials improved when supplemented with the probiotic candidate OY15 strain. Four treatments were conducted: a larval control with no bacteria, a pathogen control with larvae and pathogen B183 only, a probiotic control with larvae and probiotic candidate OY15 only, and a combination treatment composed of larvae and both probiotic and pathogen.

"Our research focused on the critical first stage of larval growth, when mortality rates are among the highest," Kapareiko said. Positive effects of probiotic candidate OY15 were found on the survival of oyster larvae (short term), on growth of phytoplankton used as larval feed, and upon oyster survival during pilot-scale larviculture conditions.

"This two-part study confirms that use of naturally-occurring probiotic bacteria confers protection to oyster larvae against bacterial disease and improves their survival," Kapareiko said. "The results can be used as guidelines for isolating and screening other potential probiotic candidates for similar aquaculture applications, and provide the basis for developing functional foods for use in shellfish hatcheries that incorporate a naturally occurring, probiotic bacteria."

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The above story is reprinted from materials provided by NOAA Fisheries Northeast Fisheries Science Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. H. J. Lim, D. Kapareiko, E. J. Schott, A. Hanif, G. H. Wikfors. Isolation and Evaluation of New Probiotic Bacteria for use in Shellfish Hatcheries: I. Isolation and Screening for Bioactivity. Journal of Shellfish Research, 2011; 30 (3): 609 DOI: 10.2983/035.030.0303
  2. Diane Kapareiko, Hyun Jeong Lim, Eric J. Schott, Ammar Hanif, Gary H. Wikfors. Isolation and Evaluation of New Probiotic Bacteria for use in Shellfish Hatcheries: II. Effects of aVibriosp. Probiotic Candidate Upon Survival of Oyster Larvae (Crassostrea virginica) in Pilot-Scale Trials. Journal of Shellfish Research, 2011; 30 (3): 617 DOI: 10.2983/035.030.0304

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/r_bG_GdHVbY/120130172617.htm

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Kelly Clarkson Announces New Single, Pays Tribute to Etta James


While Christina Aguilera had the floor during Etta James' funeral on Saturday, and used it to belt out a version of "At Last," former American Idol champion Kelly Clarkson paid tribute to the late, great artist in her own way last week, as well.

"This isn’t ‘At Last’ because everyone really covers that and so I wanted to do my favorite, actually," Kelly told a crown in New York City. "My favorite song is ‘I’d Rather Go Blind.’ So, this is for Etta!”

On Saturday night, meanwhile, during a performance in Pennsylvania, Clarkson also announced her next single, "I Forgive You." It will hit the radio any day now.

We can't wait!

Source: http://www.thehollywoodgossip.com/2012/01/kelly-clarkson-announces-new-single-pays-tribute-to-etta-james/

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Monday, January 30, 2012

FASEB releases FY 2013 funding recommendations for science agencies

FASEB releases FY 2013 funding recommendations for science agencies [ Back to EurekAlert! ] Public release date: 30-Jan-2012
[ | E-mail | Share Share ]

Contact: Lawrence Green
lgreen@faseb.org
301-634-7335
Federation of American Societies for Experimental Biology

Bethesda, MD The Federation of American Societies for Experimental Biology (FASEB) has released its annual report to Congress, Federal Funding for Biomedical & Related Life Sciences Research, FY 2013. "As a result of exciting new discoveries, we are poised to accelerate our progress in the search for cures, and it would be tragic if we could not capitalize on the many opportunities before us." said Joseph C. LaManna, PhD, FASEB President. "As other nations ramp up their investments in R&D, it would be very costly to cede our leadership in critical areas of science and technology. We recognize that these are difficult economic times. Nonetheless, it remains abundantly clear that research-based innovation has dramatically improved the quality of life for billions of people, and that our best hope for future progress remains a strong commitment to science and technology."

Below are the recommendations for the five agencies described in the report.

National Institutes of Health (NIH)
FASEB recommends an appropriation of at least $32 billion for NIH in FY 2013 as the first step of a program of sustained growth that will keep pace with the increasing scientific opportunities and the demonstrated capacity of the research enterprise.

National Science Foundation (NSF)
FASEB recommends a minimum funding level of $7.3 billion for the National Science Foundation in FY 2013 to prevent contraction.

Department of Energy (DOE), Office of Science
To promote sustainable growth, FASEB recommends a funding level of $5.1 billion for the Department of Energy's Office of Science in FY 2013.

Department of Veterans Affairs (VA)
FASEB recommends funding the Veterans Administration Medical and Prosthetic Research Program at $621 million in FY 2013.

Department of Agriculture (USDA), Agriculture and Food Research Initiative
FASEB recommends $277 million for AFRI in FY 2013.

The report outlines FASEB's research funding goals for the next fiscal year and will be sent to members of Congress and senior officials in the Obama administration. A copy of the report is available online here: http://www.faseb.org/Portals/0/PDFs/opa/1.30.12%20Fed%20Funding%20Report%20press%20release%20FINAL.pdf

###

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Celebrating 100 Years of Advancing the Life Sciences in 2012, FASEB is rededicating its efforts to advance health and well-being by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


FASEB releases FY 2013 funding recommendations for science agencies [ Back to EurekAlert! ] Public release date: 30-Jan-2012
[ | E-mail | Share Share ]

Contact: Lawrence Green
lgreen@faseb.org
301-634-7335
Federation of American Societies for Experimental Biology

Bethesda, MD The Federation of American Societies for Experimental Biology (FASEB) has released its annual report to Congress, Federal Funding for Biomedical & Related Life Sciences Research, FY 2013. "As a result of exciting new discoveries, we are poised to accelerate our progress in the search for cures, and it would be tragic if we could not capitalize on the many opportunities before us." said Joseph C. LaManna, PhD, FASEB President. "As other nations ramp up their investments in R&D, it would be very costly to cede our leadership in critical areas of science and technology. We recognize that these are difficult economic times. Nonetheless, it remains abundantly clear that research-based innovation has dramatically improved the quality of life for billions of people, and that our best hope for future progress remains a strong commitment to science and technology."

Below are the recommendations for the five agencies described in the report.

National Institutes of Health (NIH)
FASEB recommends an appropriation of at least $32 billion for NIH in FY 2013 as the first step of a program of sustained growth that will keep pace with the increasing scientific opportunities and the demonstrated capacity of the research enterprise.

National Science Foundation (NSF)
FASEB recommends a minimum funding level of $7.3 billion for the National Science Foundation in FY 2013 to prevent contraction.

Department of Energy (DOE), Office of Science
To promote sustainable growth, FASEB recommends a funding level of $5.1 billion for the Department of Energy's Office of Science in FY 2013.

Department of Veterans Affairs (VA)
FASEB recommends funding the Veterans Administration Medical and Prosthetic Research Program at $621 million in FY 2013.

Department of Agriculture (USDA), Agriculture and Food Research Initiative
FASEB recommends $277 million for AFRI in FY 2013.

The report outlines FASEB's research funding goals for the next fiscal year and will be sent to members of Congress and senior officials in the Obama administration. A copy of the report is available online here: http://www.faseb.org/Portals/0/PDFs/opa/1.30.12%20Fed%20Funding%20Report%20press%20release%20FINAL.pdf

###

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Celebrating 100 Years of Advancing the Life Sciences in 2012, FASEB is rededicating its efforts to advance health and well-being by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-01/foas-frf013012.php

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Robert Shumake ? Understanding The Real Estate Investing Tax ...

This article has been viewed 65 times.

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Source: http://articlexone.com/arts/robert-shumake-understanding-the-real-estate-investing-tax-table.html

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Sunday, January 29, 2012

Paul says he has no intention of dropping out (AP)

GORHAM, Maine ? Ron Paul said Saturday the Republican presidential race has "a ways to go" and he doesn't intend to get out or get behind another candidate anytime soon.

The Texas congressman was campaigning Saturday in Maine, which holds caucuses beginning Feb. 4. He spoke to an overflow crowd at the University of Southern Maine and held an outdoor rally outside the famed L.L. Bean store in Freeport. He picked up the endorsement of Linda Bean, the granddaughter of the Bean company founder and a prominent Republican activist in the state.

Paul told reporters that it didn't make sense for him to campaign in Florida, which holds its primary Tuesday and awards all its 50 delegates to the winner. Polling indicates Mitt Romney is leading the field there.

"Some other campaigns have many, many millions of dollars to run a campaign," Paul said. "We maximize the delegates the way we're doing it."

Paul planned to campaign next week in other caucus states, including Nevada, which also holds its caucus on Feb. 4, and Colorado and Minnesota, which hold caucuses Feb. 7.

Paul dismissed suggestions he would back any of his GOP rivals.

"I think that's premature. We have a ways to go," Paul said, adding he was glad they were speaking favorably about some of his libertarian-leaning views.

"I'll work with anybody who wants to come in the direction of Constitutional government," Paul said.

He noted that Newt Gingrich had endorsed his views on monetary policy in a nationally televised debate this week. Paul has called for the Federal Reserve to be audited and ultimately eliminated, and wants the value of the dollar tied to gold.

Paul said he hoped the former House speaker and others would also adopt his noninterventionist foreign policy views, which are far outside the Republican Party mainstream.

"If he says `I agree with Ron Paul, we should bring the troops home from Afghanistan,' my ears would pop up," Paul said.

___

Follow Beth Fouhy on Twitter at http://www.twitter.com/bfouhy

Source: http://us.rd.yahoo.com/dailynews/rss/gop/*http%3A//news.yahoo.com/s/ap/20120128/ap_on_el_pr/us_paul

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'Dead' deep sea vents are anything but dead

Volcanic seafloor vents that roar with the scalding heat of Earth's interior don't stay hot forever. Eventually, over hundreds or thousands of years, they flicker out and turn cold.

Yet new research reveals that the action on these oases of life on the seafloor doesn't stop when the heat goes off. Life goes on in the frigid dark, but on a teeny scale.

It turns out that large populations of bacteria live on expired vents, and these microbes are very different from those that thrive when the vents are piping hot, according to a study published this week in the journal mBio.

Scientists found evidence that up to 2,000 different sorts of microbes were living in a small section of a long-expired vent near the East Pacific Rise, a vast seam on the seafloor in the southern Pacific Ocean where two tectonic plates are being wrenched apart. For comparison, up to 8,000 varieties of microbes have been found living on active, hot vents, and up to 10,000 in deep seawater.

Although finding the microbes themselves didn't come as a huge shock ? scientists have found bacteria living in other types of cool seafloor rocks ? the revelation of who exactly moved in once the vents went cold was surprising, according to the study authors.

"Seeing the shift in the microbial population ? seeing who actually came and left was fairly illuminating for me," said study co-author and geomicrobiologist Katrina Edwards, a professor at the University of Southern California.

Who's there?
The samples from the East Pacific Rise vents revealed a world of bizarre biological harmony. Microorganisms that employ utterly different physiological mechanisms to survive were living almost side by side.

In other samples of seafloor rock, the microbe communities typically change gradually, shifting in a way that brings to mind a road trip across an entire country, "whereas here, it's like there are different neighborhoods, and they can change pretty drastically," said Jason Sylvan, a USC post-doctoral researcher and lead author on the paper.

Gated communities of anaerobic organisms (which don't need oxygen to survive) were parked next to gated communities of aerobic organisms, which do require oxygen.

"Finding things that are anaerobic and aerobic right next to each other was surprising," Sylvan told OurAmazingPlanet.

A living arrangement akin to a golden retriever and a trout living across the hall?

"It's probably more drastic than that, but that's the right idea," Sylvan said.

Big effects
Overall, Edwards said, the research highlights how little we know about the sheer abundance of life on the seafloor, which has implications for understanding large-scale planetary processes.

Both scientists emphasized that the deep ocean increasingly appears to play a huge role in the way carbon dioxide, a greenhouse gas that contributes to climate change, is processed by the planet's interlocking systems of atmosphere, land and ocean.

"There are all these organisms down there making biomass, and that's not accounted for in our carbon cycle at all," Edwards told OurAmazingPlanet. "The ocean floor is quite vast so there is an opportunity for these organisms to have an effect."

The research comes on the heels of splashy news from deep sea vents around the world.

Scientists recently announced the discovery of ghostly white yeti crabs swarming newfound vents near Antarctica, and bizarre shrimp with eye-like features on their backs that thrive on the deepest vents ever discovered on Earth.

Sylvan said the cold, expired vents deserve attention, too.

"When we think of hydrothermal vents we think of things that are really exciting, like hot, black smoker vents or big animals," he said, "but there are also exciting things happening that aren't necessarily visible to the naked eye."

Reach Andrea Mustain at amustain@techmedianetwork.com. Follow her on Twitter @AndreaMustain. Follow OurAmazingPlanet for the latest in Earth science and exploration news on Twitter @OAPlanet and on Facebook.

? 2012 OurAmazingPlanet. All rights reserved. More from OurAmazingPlanet.

Source: http://www.msnbc.msn.com/id/46165250/ns/technology_and_science-science/

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Saturday, January 28, 2012

Tight-fisted mortgage lenders pressure home sales

By John W. Schoen, Senior Producer

Home prices have fallen by a third since 2006, creating tremendous bargains for home buyers. Mortgage rates are at rock-bottom lows, making houses more affordable than they have been in decades. Yet home sales last year fell to the lowest levels since the government began keeping records in 1963.

One big reason: mortgage bankers have gotten a lot choosier about approving loans, according to a report by Goldman Sachs economists Hui Shan and Jari Stehn. By some measures, they're pickier than they were before the housing boom took off.?

With anecdotal evidence showing that home mortgages are harder to get, the economists crunched Federal Reserve data to show just how much tighter lending standards have become. Using the results of the Fed's survey of loan officers, the report found that lending standards rose sharply after the mortgage market collapsed and the financial system imploded in 2008. Since the recession ended in 2009, lenders haven?t eased their tight grip on mortgage money.

Part of the reason is that there?s less money available to lend. During the housing boom, as brokers produced a flood of new mortgages, Wall Street bankers churned out a torrent of mortgage-backed bonds for investors waiting to snap them up. That market has all but vanished; 90 percent of new mortgages written today are backed by the government. ??

The new mortgage pipeline also has slowed because it is clogged with paperwork. These days, you?ll have to fill out many more forms and produce a lot more documentation, on average, just to get your loan considered.

The percent of loans that required ?full documentation? declined steadily from 2000 through 2006, hitting a low of less than 60 percent. Those ?no-doc? loans were a big part of the reason mortgage bankers made the bad underwriting decisions that created the mortgage mess. Today, nearly 90 percent of mortgage applications require full documentation. That?s much higher than the pre-bubble level.

You?ll also have to show a much higher credit score than you did in the go-go days of the housing boom. In a separate report, Mortgage Marvel, an online mortgage-shopping website, analyzed data from more than 700,000 mortgage applications filed last year and found that the average FICO score was 730. That?s a significant jump from the days when borrowers with scores in the high 500s were routinely steered to high-cost subprime loans.

Applications with highest credit scores concentrated in California, Oregon, Wisconsin, District of Columbia and Hawaii, the company said. The states with the lowest credit scores were Mississippi, Arkansas, West Virginia, Louisiana? and Oklahoma.

Have you had trouble getting a mortgage approved?

Join the discussion on Facebook

Source: http://bottomline.msnbc.msn.com/_news/2012/01/27/10252614-tight-fisted-mortgage-lenders-pressure-home-sales

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Friday, January 27, 2012

Reward offered for released Mississippi murderer

Police are offering a reward to help track down a convicted murderer who was pardoned by former Gov. Haley Barbour, R-Miss. Mississippi Attorney General Jim Hood joins NewsNation to discuss the situation.

By msnbc.com staff and news services

Mississippi's attorney general is asking for the public?s help in tracking down a convicted killer who vanished weeks ago after being pardoned by former Governor Haley Barbour.

?I hate the fact that our former governor has unleashed this guy on the U.S.,? Attorney General Jim Hood told msnbc.com on Thursday. ?I equate this to having a manhunt with one arm tied behind my back.?

Authorities began looking for Ozment after the former inmate did not appear?on Monday?at a court hearing related to the pardons. Hood said he has offered an unspecified cash reward for information regarding Ozment's whereabouts.


Barbour, a former Republican National Committee chairman, sparked controversy by granting some 200 pardons, commutations and suspensions, generating debate about how much power a governor should have to pardon criminals convicted of serious crimes.

Barbour has defended his clemency decisions and said he was confident they were all valid and blamed political opponents for much of the controversy.

Ozment, 40, had been serving a life sentence for the 1993 robbery and shooting death of a store clerk in northwest Mississippi. He was one of five prisoners who had worked at the governor's mansion who saw their life prison terms lifted after receiving full pardons by Barbour.

Hood is seeking to void most of the pardons granted by Barbour because not enough public notice was given in the communities where the crimes were committed. He received a court order to temporarily block the pardons.

A judge allowed the five freed men, including Ozment, to remain out of prison while the matter was pending but required them to report daily to authorities. Ozment was the only one who has not done so, Hood said.

Hinds County Circuit Judge Tomie Green has scheduled?a hearing for Feb. 3.

Hood asked anyone with information to call a confidential hotline at 1-800-281-4418.

Msnbc.com's Sevil Omer and Reuters contributed to this report.

More content from msnbc.com and NBC News

Source: http://usnews.msnbc.msn.com/_news/2012/01/26/10245722-reward-offered-for-released-mississippi-murderer

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Thursday, January 26, 2012

AT&T's proposed spectrum transfer mapped out in T-Mobile magenta

Wondering what AT&T's proposed spectrum transfer would mean for T-Mobile? Check out the above graphic, from GigaOM. Created by a reader named Andrew Shepherd, this map displays which regional coverage T-Mobile will gain from the transfer, which was submitted to the FCC this week following the companies' failed merger. As you can see, AT&T is poised to sacrifice some of its AWS spectrum in some key markets, including Boston, Seattle and the Bay Area. According to Shepherd, however, the carrier only gave up enough AWS spectrum in areas where it had enough 700MHz capacity to fill the gap, without posing too great a risk to its LTE expansion. For a closer look, check out the source link below.

AT&T's proposed spectrum transfer mapped out in T-Mobile magenta originally appeared on Engadget on Wed, 25 Jan 2012 08:33:00 EDT. Please see our terms for use of feeds.

Permalink The Verge  |  sourceGigaOM  | Email this | Comments

Source: http://www.engadget.com/2012/01/25/att-tmobile-spectrum-transfer-map/

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Muslim guard gets $465K in Calif. harassment suit (AP)

SAN FRANCISCO ? A San Francisco jury has awarded $465,000 to a Muslim security guard who says his co-workers and supervisors called him a terrorist and an al-Qaida member.

The San Francisco Chronicle reports ( http://bit.ly/wh5c8Y) jurors added $400,000 in punitive damages Monday to their earlier $65,000 verdict in favor of Abas Idris for lost wages and emotional distress.

The 27-year-old says he quit his job as a security guard for Los Angeles-based Andrews International in February 2010 after the company failed to take his complaints about harassment seriously. He had served as a guard at the Letterman Digital Arts Center in the Presidio.

An attorney for Andrews says the company had promoted Idris to a supervisory position and plans to appeal the verdict.

___

Information from: San Francisco Chronicle, http://www.sfgate.com

Source: http://us.rd.yahoo.com/dailynews/rss/terrorism/*http%3A//news.yahoo.com/s/ap/20120125/ap_on_re_us/us_muslim_harassment_lawsuit

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Wednesday, January 25, 2012

Review: Tim McGraw's "Emotional Traffic" is serious and silly (Reuters)

LOS ANGELES, (TheWrap.com) ? Tim McGraw's "Emotional Traffic" arrives in stores as the most litigated album in recent musical/legal history. Imagine the missed opportunities for ad campaigns: Direct from the Tennessee court system to your sound system!

The real ad line is a laudatory quote found on a giant sticker on the CD shrink wrap: "'My Best Album Ever' -- Tim McGraw." That opinion contrasts with the legal position taken by Curb Records, which contended in court last year that this recording, which was meant to wrap up his deal with the label, was substandard or already dated (since he turned it in back in 2010) and he should be held to the company for further recordings.

Now that a judge has declared the star a free agent, compelling Curb to finally release "Emotional Traffic," the label would much rather that you believed McGraw's cover blurb than their own court briefs, of course.

Here's another judicial verdict: Neither is right. Probably even McGraw doesn't really believe this is his finest effort. But neither is the album the sonically antiquated throwback that Curb's lawyers risibly contended with their legal Hail Mary. Rather, it's another solid B+ effort in a career that's been full of them -- hinting at greatness when McGraw is trafficking in thematically complex balladry, settling for affability when those orange cones inevitably steer him toward good-timey rockers and humanist affirmation anthems.

No star in contemporary country has been quite so good or brave about picking songs that get at the real stresses of middle age ennui and the bitterness that can creep into long-term relationships, a la "Angry All the Time." The new release is book-ended by a pair of terrific tunes in that tradition, and they're strong enough that you can forgive some of the ephemera that passes in-between.

The opening "Halo," in particular, sets a standard the rest of the album is often hard-pressed to meet. "I'll clean up the mess, baby, you stand there and shout," McGraw sings, playing the quieter partner in a combative relationship. "I'll take it like a circus lion, silent in my cage. I'll crawl out of my cradle down into my black hole, and you'll just lay low under your halo." Ouch! A hazy lap-steel guitar and hard-rock solo guitar do a pas de deux in the atmospheric fadeout, dancing around one another a little less passive-aggressively than the couple in the lyrics.

After that downbeat an opening, it's no surprise that the album quickly takes a turn for the giddy with "Right Back Atcha Babe," which goes so far in reaffirming romanticism that McGraw promises "that ring you been waiting for all these years." It's so over-the-top in its goofy sweetness that the best way to get through the song is by thinking of it as an ironic prequel about the doomed couple in the tune that came before.

That's not to say that McGraw's upbeat material always lacks the flair of his more somber fare. "Felt Good On My Lips" (which was released a year and a half ago, and became a No. 1 hit) adds nearly novelistic detail to the thin story of a dance-floor flirtation and corner-booth make-out session. The indie-rock guitar riff that opens the tune hardly hints at the Bon Jovi-esque lengths the chorus will eventually go to, and somehow McGraw ties the melody's wildly divergent strands together with the kind of cheerful eroticism you can only find in country.

Faith Hill's lips make a guest appearance on a spirited remake of Dee Irvin's R&B chestnut "One Part, Two Part" (an idea the McGraw-Hills probably picked up from Buddy and Julie Miller's similar cover a few years ago). Less successfully, R&B star Ne-Yo shows up to duet on the artificially sweetened "Only Human," a failed attempt at recreating the cross-genre chemistry McGraw had with Nelly back on 2004's "Over and Over." A further inspirational trifecta takes hold with "I Will Not Fall Down," a Martina McBride-co-written self-help anthem full of generic bootstrap-tugging; "Better Than I Used to Be," the half-repentant current single; and "Touchstone Jesus," which may or may not leave the Almighty happy about being likened to a football champion.

After the album's veered into all those happy-go-lucky bromides, it's a relief to find it closing just as it opened -- on a downer. "Die By My Own Hand" isn't quite as grim as it sounds; suicide is only employed as a metaphor. But the "Halfway to Hazard" cover ends the album on a fatalistic note that fits in perfectly with the sad-sack side of traditional country, even as the arena-rock atmospherics ramp the recording up into near-Coldplay territory.

McGraw has indicated that he'll be putting out another album this year, on a new label, now that he's able to set his own timetable. It'd be nice if he used the transition as an occasion to record an entire album of material as weighty and strong as "Halo" and "Die By My Own Hand."

But you know what? Even a lot of the more lightweight fare feels good from his lips.

(Reporting By Bob Tourtellotte)

Source: http://us.rd.yahoo.com/dailynews/rss/music/*http%3A//news.yahoo.com/s/nm/20120124/music_nm/us_reviews_timmcgraw

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"We Are Always Getting Ready to Live but Never Living" [Quotables]

"We Are Always Getting Ready to Live but Never Living"This quote from poet and essayist Ralph Waldo Emerson is a simple reminder that we often prepare endlessly while never actually actively pursue what it is that we want. Practice is certainly important, but without applying it to real action it is nearly pointless.

It's easy to get in a path of endless preparation. You want to be your best. You want to come out of the gate being great. You don't want anyone to see the imperfect process, filled with failures, that lead you to something great. While you don't want to move forward until you're ready, often times you're ready before you know it. And there's a value in failing?it's one of the best ways to learn. So if you've been privately practicing for awhile now, consider moving forward. You may not feel ready yet, but better to give it a shot than wait forever.

Photo by Seth Sawyers.

50 Quotes on Living Well | Psychology Today

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/mQcCL-TiypA/we-are-always-getting-ready-to-live-but-never-living

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Tuesday, January 24, 2012

$25B nationwide mortgage deal goes to states (AP)

WASHINGTON ? The nation's five largest mortgage lenders have agreed to overhaul their industry after deceptive foreclosure practices drove homeowners out of their homes, government officials said Monday.

A draft settlement between the banks and U.S. states has been sent to state officials for review.

Those who lost their homes to foreclosure are unlikely to get their homes back or benefit much financially from the settlement, which could be as high as $25 billion. About 750,000 Americans ? about half of the households who might be eligible for assistance under the deal ? will likely receive checks for about $1,800.

But the agreement could reshape long-standing mortgage lending guidelines and make it easier for those at risk of foreclosure to restructure their loans. And roughly 1 million homeowners could see the size of their mortgage reduced.

Five major banks ? Bank of America, JPMorgan Chase, Wells Fargo, Citibank and Ally Financial ? and U.S. state attorneys general could adopt the agreement within weeks, according to two officials briefed on the discussions. They spoke on condition of anonymity because they are not authorized to discuss the agreement publicly.

The settlement would be the biggest of a single industry since the 1998 multistate tobacco deal. And it would end a painful chapter that grew out of the 2008 financial crisis.

Nearly 8 million Americans have faced foreclosure since the housing bubble burst. In some cases, companies that process mortgages failed to verify the information on foreclosure documents. The worst practices, known collectively as "robo-signing," included employees signing documents they hadn't read or using fake signatures to sign off on foreclosures.

President Barack Obama is expected to tout the settlement in his State of the Union address Tuesday. His administration has put pressure on state officials to wrap up a deal more than a year in the making.

But some say the proposed deal doesn't go far enough. They have argued for a thorough investigation of potentially illegal foreclosure practices before a settlement is hammered out.

New York, Delaware, Nevada and Massachusetts have argued that banks should not be protected from future civil liability. The deal will not fully release banks from future criminal lawsuits by individual states.

In December, Massachusetts sued the five major banks over deceptive foreclosure practices.

Ian McConnell, director of the fraud division for Delaware Attorney General Beau Biden, said Monday that Biden is "opposed to the proposed settlement as drafted."

"This position, given his prior public comments, should come as no surprise," McConnell said, adding that Biden will comment further when the still-confidential deal is made public.

California Attorney General Kamala D. Harris said in a statement that her ability to go after potential wrongdoing by mortgage lenders "remains a key lens through which she will evaluate any proposals." In September, California announced it would not agree to an earlier version of a settlement over foreclosure abuses that state and federal officials have been working on for more than a year.

But her office declined to comment on the proposed deal circulating among the states. And it wouldn't say whether California, the state with the greatest number of people who lost their homes to foreclosure, would agree to the deal.

New York Attorney General Eric Schneiderman, who has taken a public stance against halting investigations of fraudulent business practices as part of a national settlement, had no immediate comment Monday.

A signed deal is not expected this week, said Geoff Greenwood, a spokesman for Iowa Attorney General Tom Miller, who has led the 50-state negotiations. Greenwood said late Monday that there are "terms we must still resolve."

The settlement would only apply to privately held mortgages issued between 2008 and 2011, not those held by government-controlled Fannie Mae or Freddie Mac. Fannie and Freddie own about half of all U.S. mortgages, roughly about 31 million U.S. home loans.

As part of the deal, about 1 million homeowners could also get the principal amount of their mortgages written down by an average of $20,000. One in four homeowners with a mortgage ? or roughly 11 million people ? owe more than their home is worth. These so-called "underwater" borrowers have little chance at refinancing.

Democratic attorneys general met Monday in Chicago to discuss the deal with Housing and Urban Development Secretary Shaun Donovan. Republican attorneys general were briefed about the deals via conference call later in the day.

Under the deal:

? $17 billion would go toward reducing the principal that struggling homeowners owe on their mortgages.

? $5 billion would be placed in a reserve account for various state and federal programs; a portion of that money would cover the $1,800 checks sent to those homeowners affected by the deceptive practices.

? $3 billion would to help homeowners refinance at 5.25 percent.

In October 2010, major banks temporarily suspended foreclosures following revelations of widespread deceptive foreclosure practices by banks. Discussions then began over a national settlement.

Both sides have fought over the amounts of money that should be placed in the reserve account for property owners who were improperly foreclosed upon. Many of the larger points of the deal, including a $25 billion cost for the banks, have long been worked out, officials say.

Associated Press Writers Michael Virtanen in Albany, N.Y., Randall Chase in Dover, Del., and Ben Feller in Washington contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/ap/20120123/ap_on_bi_ge/us_mortgage_settlement

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Neil Young journeys to Utah with new concert film (AP)

PARK CITY, Utah ? Neil Young recalls how his first concert film with director Jonathan Demme was a lush, stately tribute to country music.

He says their latest, "Neil Young Journeys," is more like an electric bolt, with a "grinding, blinding beauty to it."

Their 2006 film "Neil Young: Heart of Gold" premiered at the Sundance Film Festival and was a reflective, comforting chronicle of two shows Young performed at Nashville's Ryman Auditorium alongside such longtime musical comrades as Emmylou Harris, Ben Keith and Spooner Oldham.

"Journeys" is a raw, thunderous counterpart, filmed by Demme at Toronto's Massey Hall during the closing shows of Young's solo tour last year. Solo often implies intimate and acoustic, but Young wails away on electric guitar, harmonica, piano and organ throughout the show.

The new film played Saturday at the Slamdance Film Festival, a rival showcase to Sundance. Demme says it was a fitting place because both Slamdance and the film share something of a "bad-boy" attitude.

"'Journeys' is so different from `Heart of Gold.' It's like the other side of the universe," Young, 66, said in an interview alongside Demme. "'Heart of Gold' was a massive production with great caretaking to present this whole image of this forgotten style of presenting music, in this great old chapel of country music. ...

"This film we just made is so opposite of that. It's just one person. The sound is completely different and the attitude of it is different. The look is different. ... The sounds are kind of enveloping. You get to move way inside, whereas, `Heart of Gold,' you're way back, going, `Oh, it's beautiful seeing it from the back, seeing all these beautiful people, these great musicians.' And this one here, you're like inside my instrument, inside the distortion of the guitar. There's nothing in the way."

Demme and Young seem to be on a never-ending film journey. The new movie marks the fourth film collaboration between Young and Demme, the Academy Award-winning director of "The Silence of the Lambs."

Young earned an Oscar nomination for the title song of Demme's 1993 AIDS drama "Philadelphia," and in between "Heart of Gold" and "Journeys," the two made the 2009 concert film "Neil Young Trunk Show."

"Journeys" premiered at last September's Toronto International Film Festival and has since been picked up for theatrical distribution by Sony Pictures Classics.

The film includes extreme close-ups of Young captured by a tiny camera mounted on his microphone. The camera was so close its lens catches globs of spit from Young as he's singing, adding a bit of a psychedelic tinge to the images.

"It's more distorted and funky. It's a little bit more in your face," Young said. "It's like zooming in on something, losing everything that's usually around it, and you're just losing everything else. There's no bass, no drums, there's no other guitars, there's no other voices, there's no synthesizers, there's no echo. There's just this thing. It's a big sound, because you're right up on it. It's like a fantastic voyage into your guitars."

Along with songs from Young's 2010 album "Le Noise," "Journeys" features such classics as "After the Gold Rush," "Ohio" and "Down by the River."

Intercut between the songs in "Journeys" is a road trip Young takes to one of the Toronto shows from his northern Ontario hometown of Omemee, cruising with Demme in a 1956 Ford Crown Victoria and commenting on how the towns and landscape have changed.

"This whole world of cars and music, that's a big chunk of Neil's DNA. He's all about cars and driving and music in motion," Demme said. "I don't think we had any discussions. It was just like, well, we're going to Canada to shoot the concert in Toronto. Obviously, we'll drive down there from Omemee and take a look and see what's changed, and kind of just discover the past in the present. The same way the songs are very often kind of reflective. ...

"It put a lens up to his life. He's a medium for all of our lives. Certainly, our generation, whatever Neil's been singing about for the last 40 years or whatever, it's like, `Thank you. That's exactly what I was feeling. You've put it into words and music.'"

___

Online:

http://www.slamdance.com

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/ap/20120122/ap_en_mo/us_film_sundance_neil_young

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Monday, January 23, 2012

Researchers develop gene therapy that could correct a common form of blindness

ScienceDaily (Jan. 23, 2012) ? A new gene therapy method developed by University of Florida researchers has the potential to treat a common form of blindness that strikes both youngsters and adults. The technique works by replacing a malfunctioning gene in the eye with a normal working copy that supplies a protein necessary for light-sensitive cells in the eye to function.

The findings are published Jan. 23 in the Proceedings of the National Academy of Sciences online.

Several complex and costly steps remain before the gene therapy technique can be used in humans, but once at that stage, it has great potential to change lives.

"Imagine that you can't see or can just barely see, and that could be changed to function at some levels so that you could read, navigate, maybe even drive -- it would change your life considerably," said study co-author William W. Hauswirth, Ph.D., the Rybaczki-Bullard professor of ophthalmology in the UF College of Medicine and a professor and eminent scholar in department of molecular genetics and microbiology and the UF Genetics Institute. "Providing the gene that's missing is one of the ultimate ways of treating disease and restoring significant visual function."

The researchers tackled a condition called X-linked retinitis pigmentosa, a genetic defect that is passed from mothers to sons. Girls carry the trait, but do not have the kind of vision loss seen among boys. About 100,000 people in the U.S. have a form of retinitis pigmentosa, which is characterized by initial loss of peripheral vision and night vision, which eventually progresses to tunnel vision, then blindness. In some cases, loss of sight coincides with the appearance of dark-colored areas on the usually orange-colored retina.

The UF researchers previously had success pioneering the use of gene therapy in clinical trials to reverse a form of blindness known as Leber's congenital amaurosis. About 5 percent of people who have retinitis pigmentosa have this form, which affects the eye's inner lining.

"That was a great advance, which showed that gene therapy is safe and lasts for years in humans, but this new study has the potential for a bigger impact, because it is treating a form of the disease that affects many more people," said John G. Flannery, Ph.D., a professor of neurobiology at the University of California, Berkeley who is an expert in the design of viruses for delivering replacement genes. Flannery was not involved in the current study.

The X-linked form of retinitis pigmentosa addressed in the new study is the most common, and is caused by degeneration of light-sensitive cells in the eyes known as photoreceptor cells. It starts early in life, so though affected children are often born seeing, they gradually lose their vision.

"These children often go blind in the second decade of life, which is a very crucial period," said co-author Alfred S. Lewin, Ph.D., a professor in the UF College of Medicine department of molecular genetics and microbiology and a member of the UF Genetics Institute. "This is a compelling reason to try to develop a therapy, because this disease hinders people's ability to fully experience their world."

Both Lewin and Hauswirth are members of UF's Powell Gene Therapy Center.

The UF researchers and colleagues at the University of Pennsylvania performed the technically challenging task of cloning a working copy of the affected gene into a virus that served as a delivery vehicle to transport it to the appropriate part of the eye. They also cloned a genetic "switch" that would turn on the gene once it was in place, so it could start producing a protein needed for the damaged eye cells to function.

After laboratory tests proved successful, the researchers expanded their NIH-funded studies and were able to cure animals in which X-linked retinitis pigmentosa occurs naturally. The injected genes made their way only to the spot where they were needed, and not to any other places in the body. The study gave a good approximation of how the gene therapy might work in humans.

"The results are encouraging and the rescue of the damaged photoreceptor cells is quite convincing," said Flannery, who is on the scientific advisory board of the Foundation Fighting Blindness, which provided some funding for the study. "Since this type of study is often the step before applying a treatment to human patients, showing that it works is critical."

The researchers plan to repeat their studies on a larger scale over a longer term, and make a version of the virus that proves to be safe in humans. Once that is achieved, a pharmaceutical grade of the virus would have to be produced and tested before moving into clinical trials in humans. The researchers will be able to use much of the technology they have already developed and used successfully to restore vision.

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The above story is reprinted from materials provided by University of Florida Health Science Center. The original article was written by Czerne M. Reid.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. William A. Beltran, Artur V. Cideciyan, Alfred S. Lewin, Simone Iwabe, Hemant Khanna, Alexander Sumaroka, Vince A. Chiodo, Diego S. Fajardo, Alejandro J. Rom?n, Wen-Tao Deng, Malgorzata Swider, Tomas S. Alem?n, Sanford L. Boye, Sem Genini, Anand Swaroop, William W. Hauswirth, Samuel G. Jacobson, Gustavo D. Aguirre. Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1118847109

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/01/120123163412.htm

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What You Missed While Not Watching the Last South Carolina GOP Debate (Time.com)

0 minutes. The CNN spaceship is set to launch, with blue gels on the lights that give the auditorium an alien aquarium vibe. It's the 17th GOP debate of 2012 cycle. Roll the intro montage: "Welcome to the South, the heart of the Republican Party," says the hokey disembodied voice, doing his best imitation of a Stephen Colbert send up, "where tradition lives and values matter." What? Do Iowa and New Hampshire not care about tradition and values? Nonsense. But we push on. We are veterans. We have learned to let the silly slide.

2 minutes. Each candidate gets a shout out. Former Massachusetts governor Mitt Romney is "the frontrunner." Texas Rep. Ron Paul is "the insurgent." Rick Santorum has "renewed momentum," though recent polls show it is in the wrong direction. Newt Gingrich is "on the rise." Then each of the men take the stage with their variation of a high school dweeb strut. Romney is third, and the most talkative. "Hi guys," he says to the others. "Newt," he says shaking Gingrich's hand. "Ha ha," he says, because perhaps it is funny to be shaking Gingrich's hand. "And then there were four," he adds, because that is all that remain. (See "What You Missed While Not Watching the Final Iowa Debate.")

5 minutes. CNN pomp is unending, as usual. After Twitter and Facebook mentions, some military cadets sing the national anthem. The crowd turns to a flat-screen projection of Old Glory. "That was fabulous. Absolutely fabulous," CNN host John King says afterward. One day the debate will start. Then he asks the candidates to make short opening statements. For those who speak Republican, this means brag about your brood.

7 minutes. Santorum begins, noting his "wife Karen and our seven children." He also thanks Iowa "for a little delayed but most welcome victory there." Romney beats Santorum, not in Iowa, but in brood count. "I'm married now 42 years. I have five sons, five daughters-in-law, 16 grandkids, and they're the joy of my life." The married-a-long-time thing is a knock on thrice-married Gingrich, though Romney would probably swear to his grave that this is not true. Gingrich eschews brood stats for geographic pandering. "As a Georgian, it feels good to be back at home in the South," he says. Paul mentions that he has been elected to Congress 12 times, 30 years as an obstetrician, and "I'm the only U.S. veteran on this stage tonight." (See "What You Missed While Not Watching the GOP National-Security Debate.")

9 minutes. Finally a question, and it's a doozy. Would Gingrich like to respond to his second wife's claim that he wanted an open marriage more than a decade ago? "No, but I will," he says, looking ornery. The crowd likes his attitude. "I am appalled that you would begin a presidential debate on a topic like that." The crowd is on its feet applauding. "To take an ex-wife and make it two days before the primary a significant question for a presidential campaign is as close to despicable as anything I can imagine." The place is going nuts. Gingrich goes on for a while. Then he adds, as if it no longer matters, "The story is false."

11 minutes. Gingrich is still going. "I am tired of the elite media protecting Barack Obama by attacking Republicans." A second standing ovation. If being President only required an ability to rile the public into rage against the press, America wouldn't need an election. There would be a coronation.

12 minutes. King asks Santorum if this open marriage/mistress stuff is an issue. Santorum says yes, as softly as he can. "These are issues of our lives and what we did in our lives," he says. "They are issues of character for people to consider."

13 minutes. Romney won't go there. "John, let's get on to the real issues is all I've got to say." The crowd likes that too.

14 minutes. Paul uses his turn at the Gingrich mistress plate to say media corporations are bad. "What about the corporations that run the media?" he asks, before joining in the media's attack by adding apropos of nothing in particular that he has been married 54 years.

15 minutes. New topic. Unemployment. Name three things you would do to help reduce it. Paul says "sound currency," less regulations and near-zero income taxes. Gingrich says repeal Dodd-Frank, increase domestic oil and gas exploration, and radically overhaul the Corps of Engineers.

18 minutes. King follows up by asking Gingrich to attack Romney for his work at Bain Capital. Gingrich indulges, describing "Bain Capital's model, which was to take over a company and dramatically leverage it, leave it with a great deal of debt, made it less likely to survive."

19 minutes. Romney is asked to respond, and attacks Obama. "You've got to stop the spread of crony capitalism. He gives General Motors to the UAW. He takes $500 million and sticks it into Solyndra. He -- he stacks the labor stooges on the NLRB so they can say no to Boeing and take care of their friends in the labor movement," he says. The crowd rewards the Obama bashing with applause.

20 minutes. King persists on Bain, asking Romney to explain how he comes up with the figure of 120,000 jobs created at the firm. Romney says that is what four companies he started now employ. "I'm someone who believes in free enterprise," he continues. "I think Adam Smith was right. And I'm going to stand and defend capitalism across this country, throughout this campaign." Then he turns it up a notch. "I know we're going to get hit hard from President Obama, but we're going to stuff it down his throat and point out it is capitalism and freedom that makes America strong." The foie gras attack.

22 minutes. Santorum distinguishes between regular capitalism and the "high finance" of Romney. "We need a party that just doesn't talk about high finance and cutting corporate taxes or cutting the top tax rates," Santorum says. "We need to talk about how we're going to put men and women in this country, who built this country, back to work in this country in the manufacturing sector of our economy." He's the Joe Biden of the GOP. Pure Scranton.

24 minutes. Talk about the challenges faced by returning military veterans. Everyone on stage is concerned. Paul says he worries about the high rate of suicide. Santorum says there should be job preferences. Romney says he wants the states to do much of the work. Gingrich says cut taxes and help veterans with a program like the G.I. Bill after World War II.

31 minutes. Question on ObamaCare. Romney says repeal it and replace it with something "like a market, a consumer market, as opposed to have it run like Amtrak and the post office." This is not an accurate description of how ObamaCare works, but let it slide. Move on. Gingrich says he'd "repeal all of it because I so deeply distrust the congressional staffs that I would not want them to be able to pick and choose which things they cut." By this logic, congressional staff would never get to do any legislating. But let it slide. Move on. (See "What You Missed While Not Watching the CNBC 'Oops' Republican Debate.")

35 minutes. Santorum uses this opportunity to attack both Romney and Gingrich for once supporting the individual mandate in ObamaCare. He calls Romney's health reforms in Massachusetts "an abject disaster." Romney objects. "First of all, the system in my state is not a government-run system," he says. This is true, but it is kind of funny to hear Romney say it, since he just mischaracterized ObamaCare as a "government-run system." Let it slide. Move on.

39 minutes. They go back and forth for a while, covering old ground. At one point, Romney does another "Ha ha," to express condescension at the attacks on him. When it comes around to Gingrich, he changes the subject by saying, again, that he wants 3-hour debates with Obama. "I will let him use a teleprompter. I would just rely on knowledge. We'll do fine." A real crowd-pleaser that Gingrich.

42 minutes. After more needling from Santorum, Gingrich admits he was wrong about the individual mandate.

43 minutes. Paul finally gets a chance to talk again. He says government should not be involved in medicine. Then he pivots to a discussion about why U.S. military bases overseas are bad, as are recent military adventures.

45 minutes. That brings us to the first break. Before cutting to commercial, King says Gingrich has released his tax returns while the candidates have been on stage. Nice trick. Can we expect gimics like this in future debates?

49 minutes. We're back. King promptly gets Gingrich and Santorum fighting again. "Grandiosity has never been a problem with Newt Gingrich," Santorum says. "I don't want a nominee that I have to worry about going out and looking at the paper the next day and worrying about what he's going to say next." That is a line taken almost word-for-word from the Romney campaign. Then Santorum says he finished ahead of Gingrich in New Hampshire, which is not true. Gingrich got 49 more votes. Nonetheless, Santorum accuses Gingrich of having "not cogent thoughts."

53 minutes. Gingrich responds by listing pretty much everything good that happened during his two decade run in the U.S. House. Then he says, "I think grandiose thoughts. This is a grandiose country of big people doing big things." Applause of course. More tit for tat follows. But no more fancy words like grandiose.

56 minutes. Romney tries to chime in by saying that this squabbling just shows he's the outsider who can fix Washington. But Romney does it really awkwardly, describing himself as someone "who's lived in the real streets of America." Not clear if he is referring to the old family mansion in Belmont, Mass., or the beach house in La Jolla, Calif., or the Deer Valley, Utah, lodge he once owned. Or maybe another "real street" he has yet to disclose. In the middle of the answer, Romney gets lost. Then he finds his way, and attacks Gingrich for not really having as much to do with Ronald Reagan as he claims. "You're mentioned once in Ronald Reagan's diary," Romney says.

58 minutes. Gingrich shoots back. "You did very well under the rules that we created to make it easier for entrepreneurs to go out and do things," he says to Romney. "I don't recall a single day saying, 'Oh, thank heavens Washington is there for me,'" Romney responds.

59 minutes. Question for Paul. Will he release his tax returns? "I'd probably be embarrassed to put my financial statement up against their income," he jokes of the others on the stage.

60 minutes. Romney cleans up his big mistake from the last debate, and says he will release his tax returns in April. Then, as he always does when uncomfortable, he attacks Obama. "You've got a President who's played 90 rounds of golf while there are 25 million Americans out of work," Romney says.

63 minutes. Santorum says he will release his returns as soon as he gets home and prints them off his computer.

64 minutes. King asks Romney if he will release 12 years of his tax returns, like his father George Romney did when he ran in 1968. Romney smiles at the mention of his father, but doesn't answer the question. "Maybe," he says, as the crowd starts to boo. "You know, I don't know how many years I'll release."

66 minutes. King asks a question premised on the fact that the best example of American corporate success at the moment, Apple Inc., has 500,000 employees in China and much fewer in the United States. This allows Santorum to get another Joe Biden riff going about revitalizing American manufacturing. Paul sees the question as an opportunity to deliver an economics lesson on the benefits of trade. Then Paul and Santorum bicker about Santorum's one-time aversion to a national right-to-work bill.

71 minutes. King asks a question about the recent bills in Congress that would put new restrictions on websites to protect intellectual property. He also discloses that CNN's parent company, Time Warner, which is also TIME's parent company, is a big supporter of these bills. The mention of the corporate monster responsible for The Hangover II and Harry Potter VII earns lots of boos from the crowd. "You're asking a conservative about the economic interests of Hollywood," Gingrich jokes. Bottom line, Romney, Gingrich and Paul are against the bills. Santorum is against the bills as well, but more eager to find some new rules to further protect intellectual property. "Where in America does it say that anything goes?" Santorum asks. There are some places, but Santorum has probably never been to them.

76 minutes. Break number two. Say what you want about the evils of Time Warner, but at least it allows CNN to go light on the commercial breaks.

78 minutes. We're back. No we're not. Another commercial break. Ignore the corporate backscratching at minute 76. Another movie made by Time Warner: Cats and Dogs -- The Revenge of Kitty Galore.

81 minutes. Back for real this time. The candidates are asked for one thing they would do over in the campaign. Gingrich says he would skip the first three months of the campaign when he "hired regular consultants and tried to figure how to be a normal candidate." Romney jokes that he would "get 25 more votes in Iowa." That's funny. Then Romney adds, "I guess I also would go back and take every moment I spent talking about one of the guys on the stage and spend that time talking about Barack Obama." This is disingenuous, but on message, and thus an apt summary of Romney's apparent strength and weakness. (As Romney says it, his campaign is blitzing reporters with more anti-Gingrich agitprop by e-mail.) Paul and Santorum can't think of anything they would do differently.

84 minutes. Immigration time. Same as before. Build a fence. Etc. Just look through previous "What You Missed" summaries to get the idea.

95 minutes. Abortion time. Gingrich attacks Romney for changing his mind on the issue. "Governor Romney has said that he had a experience in a lab and became pro-life, and I accept that," Gingrich says. Experience in a lab. Priceless. Then Gingrich says that Romney still appointed pro-choice judges, and still allowed for Planned Parenthood to benefit from his state health reforms. Santorum piles on, saying the country needs a pro-life crusader, not just a pro-life politician. It's like a tag team. At one point Gingrich even says, "I'll yield to Senator Santorum." Romney defends himself by pointing out that he had little choice, given the state he was in, and says he really is pro-life.

103 minutes. Paul finally gets a chance to speak again. He gets into a spat with Santorum about his own pro-life record. Paul calls abortion "a violent act" that should be handled by state, not federal, law; Santorum disagrees. At one point, Paul says to Santorum, "You are overly sensitive."

107 minutes. Final break.

111 minutes. We're back. King asks for closing arguments. Paul talks about liberty. Gingrich talks about certain doom if Obama is reelected, and suggests he is the only person who can defeat Obama. Romney lapses into his stump speech, quoting from the Declaration of Independence, and whatnot. Santorum argues that you need a conservative who will draw a sharp contrast with Obama. (See "What You Missed While Not Watching the Las Vegas GOP Debate.")

118 minutes. "That concludes our debate this evening," says King. And so it does. Four candidates still remain. No one knows how many more Republican debates are left. Should they go the way of that one pizza guy, they too won't be missed.

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