No need to file income tax returns if ? | Strategic Growth- Managing ...

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31^st July is approaching soon and millions of tax payers are worried about filing income tax returns. However this year not everyone has to go through tax filing procedure.

The Central Board of Direct Taxes (CBDT) has exempted salaried employees from the requirement of filing the returns for assessment year 2012-13. The exemption from filing I-T returns is applicable only if ?the total income of the employee does not exceed Rs 5 lakh and all following conditions are fulfilled.

1. The employee has earned only salary income and income from savings bank account and the annual interest earned from savings bank account is less than Rs 10,000.

2. The total Income of the employee does not exceed Rs 500,000 (total income means gross total income minus deductions under Chapter VIA).

3. The employee has reported his PAN to the employer.

4. The employee has reported his income from interest on savings bank account to employer.

5. The employee has received Form 16 from his employer.

6. Total tax liability of the employee has been paid off by the employer by way of TDS and the employer has deposited the TDS with Central government.

7. The employee has no refund claim.

8. The employee has received salary only from one employer.

9. The employee has not received any notice from the Income Tax Department for filing of

Earlier, it was obligatory for all salaried persons to file income tax returns under the Income Tax Act, 1961.

Tax payer has to worry less as this year income tax department had made special arrangement,? As per tax department officers special counters will? be set up in Delhi and ?Tax Kiosks? in various parts of Mumbai to assist people in filing income tax returns.

The Mumbai Income Tax Department will set up ?Tax Kiosks?, manned by Tax Return Preparers, at various locations in city to assist individual and HUF taxpayers in preparation and filing of the returns. Prescribed fees of Rs.250/- per return shall be payable by the taxpayers to such TRPs.

?NOTIFICATION?NO. 9/2012 [F. NO.225/283/2011-ITA(II)], DATED 17-2-2012 can found on

http://law.incometaxindia.gov.in/DIT/Notifications.aspx

Source: http://strategic-growth.in/finance/index.php/no-need-to-file-income-tax-returns-if/

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Dead Trigger now free and updated with new content

 

Yesterday we heard that Dead Trigger would be offering a bunch of new weapons for dealing with the zombie apocalypse, but what we didn't know is that the game would be going free to play. This is great news, considering how much the game leans on in-app purchases. Here's a recap of the new features. 

• New weapons: Chain Saw, Lewis Machine Gun, Marine Engine with blades and American West Rifle
• New gadget: Head-Flator X100 to inflate the heads of zombies to XXXL size!
• New zombies: mutated mobsters or armoured SWAT members
• New environments: underground car park or secret research base
• Survival arena, that is tailor-made for massacre of hordes of zombies
• Daily rewards
• Casino: try your luck with a slot machine
• Save game data with cloud backup
• Support Adreno 205, including Sony Xperia Play

Madfinger Games warns that folks with a Samsung Galaxy Nexus or a Nexus 7 running 4.1.1 shouldn't install due to an issue on Google's side that causes the game to force close after opening. As for other devices, the developer promises that they're gradually adding more and more support as fast as they can. iPhone and iPad owners can expect this updating landing on the iOS side sometime next week. 

You can get downloading at the link below, or check out my review of the game over at iMore. It's an awesome, action-packed game with stellar graphics and more than a little bit of goofiness. Anyone else eager to try out the Head-Flator X100?

Download: Dead Trigger

Source: http://feedproxy.google.com/~r/androidcentral/~3/4s70ayhLeZ8/story01.htm

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GE second-quarter earnings top Wall Street view, revenue light

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Source: http://news.yahoo.com/ge-profit-continuing-operations-2-5-percent-104217892--sector.html

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3-D tumor models improve drug discovery success rate

ScienceDaily (July 19, 2012) ? Imagine millions of cancer cells organized in thousands of small divots. Hit these cells with drugs and when some cells die, you have a candidate for a cancer drug. But a review published this week in the journal Expert Opinion on Drug Discovery argues that these 2D models in fact offer very little information about a potential drug's effects in the body and may often give researchers misleading results.

"Up until the 1980s animal models were the standard for cancer drug discovery. However, with the increase in the number of compounds available for testing and the advent of high-throughput screening (HTS), the use of animals to discover cancer drugs became too costly and unethical. Consequently, 2D cell culture models have become the mainstay for drug discovery or to explore a drug's mechanism of action," says Dan LaBarbera, PhD, investigator at the University of Colorado Cancer Center and the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences. LaBarbera is principal investigator of the recent review, on which he collaborated with Skaggs colleagues Brian Reid, PhD, and Byong Hoon Yoo, PhD.

LaBarbera cites the gap between results in 2D cells and effects in tumors themselves as a contributing factor for the declining rate of drugs passing FDA approval. In particular, only 5 percent of investigational new drugs targeting cancer make it through clinical trials, at a cost of about $800 million per drug. When you factor in the inevitable failures at various points in development, each approved drug costs an average $1.5 billion.

To increase the drug success rate, LaBarbera suggests something called the multicellular tumor spheroid (MCTS) model. In these models, instead of 2D monolayers, cancer cells are cultured as 3D spheroids. One of the advantages of the MCTS model is that when spheroids reach a critical diameter, they begin to form an outer proliferating zone, an inner quiescent zone, and a central necrotic core -- more faithfully mimicking the microenvironments of human tumors. Additionally, spheroids can be grown in the presence of compounds that mimic extra cellular matrix -- the environment that surrounds and very much affects the growth and behaviors of human tumors.

Instead of indiscriminately killing cells, modern cancer drugs tend to target cells with very specific genetic mutations that turn on and off very specific growth and survival mechanisms that in turn very frequently depend on everything else going on in and around the cells. Using MCTS models, researchers can ask questions about how a drug will penetrate a tumor's heterogeneous 3D structure and how a drug will interact with the environment surrounding these tiny tumors.

"Though these MCTS models have been around since the 1970s, only recently has technology made it possible to use them in place of 2D models for the high-throughput screening used in drug discovery," LaBarbera says.

Remember those millions of cancer cells organized in independent divots that researchers hit with drugs? We're fairly tied to the technology that reads the results of these divots. But micro-technologies now allow multicellular tumor spheroids to be cultured in place of 2D cell cultures using high-throughput micro-well plates -- we can use the same drug testing machinery on these new models. Likewise, materials science technology now exists to grow cells within semipermeable membranes, helping researchers define the shape of the eventual spheres. And as futuristic as it undoubtedly sounds, magnetic cell levitation can help alleviate the problem of cells sticking to the plastic well surface, which limits spheroid growth.

The recent practicality of high-throughput MCTS screening leads LaBarbera to call today a "renaissance" for the technique.

Of course, this 3D testing is initially more expensive and more challenging. "A lot of researchers try to get cost down to pennies per well -- you can see how screening millions of compounds equals millions of dollars -- but this often leads to a higher cost down the road due to a lower success rate. Yes, it may cost more to do HTS with 3D models, but in the long run it may lead to higher success rates and so decreased costs," LaBarbera says.

LaBarbera suggests that another use of the systems biology approach made possible by 3D models like MCTS is to bridge the gap between high-volume, low-accuracy screens and more involved testing in animal models.

"We envision a future in which MCTS arrays enable a convergence of systems biology and chemical biology, improving the success rate of drugs in the pipeline of discovery," LaBarbera says.

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---

Story Source:

The above story is reprinted from materials provided by University of Colorado Denver. The original article was written by Garth Sundem.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Labarbera DV, Reid BG, Yoo BH. The multicellular tumor spheroid model for high-throughput cancer drug discovery. Expert Opin Drug Discov., 2012 Jul 12 [link]

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/07/120720092230.htm

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Queen greets Olympic torch at Windsor Castle

This image made available by LOCOG shows torchbearer 048 Sarah Winckless carrying the Olympic Flame at the Olympic Rowing Venue, Eton Dorney, England on the Torch Relay leg on Eton Dorney Lake Tuesday July 10, 2012. (AP Photo/Gareth Fuller)

This image made available by LOCOG shows torchbearer 048 Sarah Winckless carrying the Olympic Flame at the Olympic Rowing Venue, Eton Dorney, England on the Torch Relay leg on Eton Dorney Lake Tuesday July 10, 2012. (AP Photo/Gareth Fuller)

In this image provided by the Olympic Organizing Committee LOCOG, showing Sir Roger Bannister holding the Olympic Flame on the running track at Iffley Road Stadium in Oxford, England, Tuesday July 10, 2012. Bannister was the first person to ever to run a sub four-minute-mile, on May 6, 1954, at this track in Oxford. Bannister returned to the site of his greatest sporting achievement, to participate in the Olympic Torch relay as the Olympic flame is carried around the country to the opening ceremony of the 2012 London Olympic Games. (AP Photo / Gareth Fuller, LOCOG)

Sir Roger Bannister talks to the media before passing the Olympic Flame to a torchbearer on the running track at Iffley Road Stadium in Oxford, England, Tuesday July 10, 2012. Bannister was the first person ever to run a sub four-minute-mile, on May 6, 1954, at this track in Oxford. Bannister returned to the site of his greatest sporting achievement, to participate in the Olympic Torch relay as the Olympic flame is carried around the country to the opening ceremony of the 2012 London Olympic Games. (AP Photo/Lefteris Pitarakis)

This image made available by LOCOG shows former Colombian soccer player Carlos Valderrama carrying the Olympic Flame on the Torch Relay leg between Slough and Windsor, England, Tuesday July 10, 2012. (AP Photo/Danny Lawson, LOCOG)

This image made available by LOCOG shows former Colombian soccer player Carlos Valderrama carrying the Olympic Flame on the Torch Relay leg between Slough and Windsor, England, Tuesday July 10, 2012. (AP Photo/Danny Lawson, LOCOG)

LONDON (AP) ? Queen Elizabeth II has met an old flame ? the fire lit in Greece to mark the London Olympics.

The monarch carried an unopened umbrella Tuesday as torchbearer Gina Macgregor held the torch. The sodden 74-year-old runner joked about being caught in downpour and told the queen that she had "looked fine this morning."

The flame's visit to Windsor Castle came on an eventful day for the relay, which began with the torch being held aloft by Roger Bannister, the first runner to smash the 4-minute mile in 1954.

The torch is winding its way 8,000 miles (12,900 kilometers) across the country ahead of the July 27-Aug. 12 Olympics. Organizers say the flame should come within 10 miles (16 kilometers) of 95 percent of the population.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-07-10-London%202012-Torch/id-dad8b79d7c60451d8b33d939e5ce1dcf

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Dwarkadelhi Blog ? Very good Personal Finance Guidance For Any ...

Previous Post: Natural Allergy Aid: Is It Attainable? &nbsp Next Post: Exceptional Strategies To Assist You Stop Smoking

Personal finance is concerning how to greatest devote your hard earned money to help you continue to have some when you really need it. It involves budgeting, investing and everything in the middle. This information will give you several recommendations that you are currently sure to find helpful.

Do stuff your self. Would you typically get the fingernails or toenails done? Paint them yourself. Do you have a grass routine maintenance man or woman? Mow the grass on your own. Understanding how to do things yourself allows you to learn a new talent, additionally it lets you cut costs rather than pay someone else to get it done.

Save your money in a free account that has substantial yields. Make sure it is FDIC covered by insurance, that there is absolutely no chance involved, and that you can accessibility your hard earned money when you want it. Accounts like these might appear difficult to find, but a little research will compensate you together with aid your expense develop.

1 effective way to keep your private finances in good shape is to repay your credit card balances in full on a monthly basis. Paying merely the bare minimum needed can lead to expensive financial charges that will amount to a significant amount of cash. Paying your balances completely is a brilliant strategy to handle your own financial situation.

Many people opt for 15-calendar year home mortgages to get their homes repaid more quickly. This sometimes places them in a stressful situation in the event the payments are extremely substantial. Rather, try spending a single extra mortgage payment annually. This simple technique can shave several years off your mortgage loan, and you may rarely see the more annual settlement!

For those who have a habit of throwing change in the bottom of any cabinet or leaving behind bills crumpled within your jacket pockets, cease it! Locate all your tiny chances and ends of cash and acquire them jointly in a single. Matter it all up, and if it?s a large sufficient volume, use it to open just a little savings account. From now on, put all that free change in a piggy bank or other compartment and deposit it inside your bank account regularly.

Should you rent your property, provide you with renters insurance plan to cover you in case of a reduction, such as fireplace, wind harm and burglary. Renters insurance policies are extremely affordable. If you have an all natural tragedy, the owner of your home is included for loss of home however you are not taken care of except if you have your personal policy.

As was mentioned before in this article, controlling personal financial situation is just not a fairly easy action to take. To actually deal with your money, and make your cash work for you, takes a lot of training and effort. By cautiously reading this article, and using everything you discover, you may take the very first techniques towards improving your personal finances.

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Source: http://blog.dwarkadelhi.com/?p=32932

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